<p>Each graph depicts glucosylsphingosine levels in four tissues from mice having the same <i>Gba 1</i> mutation: D409H (9H/9H and 9H;C*), V394L (4L/4L and 4L;C*), D409V (9V/9V, 9V/null and 9V;C*) and N370S (0S/0S and 0S;C*). Age-matched WT tissues were included as control. The data analyses were as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057560#pone-0057560-g002" target="_blank">Figure 2</a>.</p
<p>(A) GlcCer concentration in visceral tissues. The lungs, livers and spleens from 9-, 18-, 28- and...
<p>(<b>A</b>) GAA and glycogen levels were assessed in tissue lysates prepared from heart and gastro...
<p><i>Gne<sup>M712T/M712T</sup> (grey)</i> mouse muscle experienced reduced levels of GM3 gangliosid...
<p>The fold changes of GC species and glucosylsphingosine levels in individual mutant mice were age-...
<p>(A) The mean proportion of each GC species relative to total GC (6 GC species) in age-matched <i>...
Gaucher disease results from GBA1 mutations that lead to defective acid b-glucosidase (GCase) mediat...
Gaucher disease results from GBA1 mutations that lead to defective acid β-glucosidase (GCase) mediat...
<p>Each panel presents GC species levels in mice having the indicated <i>Gba1</i> mutation: D409H (9...
<p>Total GC levels in liver, lung, and spleen from 9V/null (red), 9H/9H (violet), 9V/9V (green), and...
a<p># indicates significantly changed GC species level relative to WT. Data present mean of 3–4 mice...
Glucosylceramide and glucosylsphingosine are the two major storage products in Gaucher disease (GD),...
Gaucher disease is a lysosomal storage disease caused by defective activity of acid β-glucosidase (G...
a<p>Summarized from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057560#po...
Gaucher disease is caused by a deficiency in glucocerebrosidase that can result in non-neuronal as w...
<div><p>Brain homogenates were treated with or without PK as indicated prior to SDS PAGE analysis.</...
<p>(A) GlcCer concentration in visceral tissues. The lungs, livers and spleens from 9-, 18-, 28- and...
<p>(<b>A</b>) GAA and glycogen levels were assessed in tissue lysates prepared from heart and gastro...
<p><i>Gne<sup>M712T/M712T</sup> (grey)</i> mouse muscle experienced reduced levels of GM3 gangliosid...
<p>The fold changes of GC species and glucosylsphingosine levels in individual mutant mice were age-...
<p>(A) The mean proportion of each GC species relative to total GC (6 GC species) in age-matched <i>...
Gaucher disease results from GBA1 mutations that lead to defective acid b-glucosidase (GCase) mediat...
Gaucher disease results from GBA1 mutations that lead to defective acid β-glucosidase (GCase) mediat...
<p>Each panel presents GC species levels in mice having the indicated <i>Gba1</i> mutation: D409H (9...
<p>Total GC levels in liver, lung, and spleen from 9V/null (red), 9H/9H (violet), 9V/9V (green), and...
a<p># indicates significantly changed GC species level relative to WT. Data present mean of 3–4 mice...
Glucosylceramide and glucosylsphingosine are the two major storage products in Gaucher disease (GD),...
Gaucher disease is a lysosomal storage disease caused by defective activity of acid β-glucosidase (G...
a<p>Summarized from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057560#po...
Gaucher disease is caused by a deficiency in glucocerebrosidase that can result in non-neuronal as w...
<div><p>Brain homogenates were treated with or without PK as indicated prior to SDS PAGE analysis.</...
<p>(A) GlcCer concentration in visceral tissues. The lungs, livers and spleens from 9-, 18-, 28- and...
<p>(<b>A</b>) GAA and glycogen levels were assessed in tissue lysates prepared from heart and gastro...
<p><i>Gne<sup>M712T/M712T</sup> (grey)</i> mouse muscle experienced reduced levels of GM3 gangliosid...