<i>Nf1</i> OPG mice display context-dependent alterations in activity in the elevated plus maze (EPM).

<p>No differences were observed in the distances traveled by the <i>Nf1</i> OPG mice compared to the WT littermate control group from cohort 2 (4.5 months old) in either the open arms (A) or in the center area of the EPM (B). (C) However, the <i>Nf1</i> OPG mice traveled a significantly shorter total distance throughout the entire EPM compared to the control group (Genotype effect: ^††p = 0.009) with significant differences between groups occurring on Test Days 2 (*p = 0.015) and 3 (**p = 0.009). (D) The differences in total distance traveled were found to be mostly due to differences between the two groups in distance traveled in the relatively non-threatening closed arms. Specifically, the <i>Nf1</i> OPG mice, on average, traveled a significantly shorter distance in the closed arms compared to the WT controls (Genotype effect: ^††p = 0.0015), with significant differences being found on Test Days 2 (**p = 0.003) 3 (*p = 0.006), although large differences were also found on Test Day 1 as well (^†p = 0.024). For both groups in cohort 2 the sample sizes were the same (n = 10), as was the sex distribution (M = 4; F = 6).