General behaviour and spatial memory are preserved in <i>EfnB1</i> mutant mice.

<p><i>A.</i> Locomotor activity and anxiety levels in <i>EfnB1</i> mutant (<i>EfnB1^Y/−</i>) mice as compared to control (WT) mice. <i>B.</i> Graph presenting swim path length as a function of individual training sessions (S1–S4). Throughout the training sessions, <i>EfnB1^Y/−</i> mice learned equally well to locate the hidden platform and exhibited decreasing swim distances over blocks of trials (F_3,45 = 12.58, <i>p</i><0.001). <i>C.</i> Number of annulus crossings during probe tests. All groups of mice showed similar preference for the target zone where the platform was located during training sessions as compared to the adjacent (Adj1 and Adj2) and opposite zones (target <i>vs</i> others, **<i>p</i><0.01; ***<i>p</i><0.001). <i>D.</i> Performances in the object location task are expressed as the group mean (± SEM) preference index. The horizontal line represents equal exploration of the two objects. <i>EfnB1^Y/−</i> and WT mice presented the same level of reaction to the object displacement (F_1,17 = 0.139, <i>p</i> = 0.714) and spent significantly more time exploring the displaced object than the non-displaced one (^###p<0.001; index <i>vs</i> chance level (50%)). NS: not significant.