Open field and elevated plus maze activity in IL-1R1^−/− and WT mice.

<p>(a) Distance travelled in open field in IL-1R1^−/− mice (n = 11) compared to WT (n = 19) and (b) the number of rears recorded in open field, across 3 minutes. (c) The time spent in open arms of elevated plus maze and (d) the latency to first emerge from closed arm. Data are expressed as mean ± SEM and significant differences by t -test are denoted by ***p<0.0001 and *p<0.05.