Adipokine, IGF-1, IGFBP-3, and insulin levels among CR, control, and DIO mice.

<p>Levels of <b>A</b>) IGF-1, <b>B</b>) IGFBP-3, <b>C</b>) insulin, <b>D</b>) leptin, <b>E</b>) resistin, and <b>F</b>) adiponectin were measured in the serum of the mice ten weeks after the last injection of AOM. Each boxplot represent the mean and range (n = 20). Overall differences among groups were determined using a one-way ANOVA. For <b>A</b>) IGF-1, p = 0.002; <b>B</b>) IGFBP-3, p<0.001; <b>C</b>) insulin, p = 0.002; <b>D</b>) leptin, p<0.0001; <b>E</b>) resistin, p = 0.001; and <b>F</b>) adiponectin, p = 0.14. <i>a</i>,<i>b</i>, and <i>c</i> represent dietary treatments that are significantly different (p<0.05) from one another as determined by a Bonferroni test.