<p>(A) Plot of <i>I-V</i> curves from eLIF models using different Δ<sub><i>T</i></sub> (2, 5, 15 mV) values, as well as a completely passive model. (B) Plot of input resistance as a function of membrane voltage for models outlined in <i>A</i>. Note, average stellate cell values are best matched by an eLIF using a Δ<sub><i>T</i></sub> value of 15 mV. (C) Voltage trajectories for initial spike approach (i) and interspike interval (ii) for models outlined in A. For comparison, average stellate cell trajectories are also shown. (D) <i>f-V</i> curves for models outlined in A. (F) Plot comparing experimental values for power-law function exponent in stellate cells and eLIF model using a Δ<sub><i>T</i></sub> of 15 mV.</p
A. Frequency vs. Ibias curves for LIF (blue) and INaP (red) models. Observe the different scales for...
<p>Simulations of membrane potential (blue curves) and habituative transmitter (red curves) traces i...
<p>In <i>Step 1</i> (first row), the experimental spike train <i>S</i><sub>data</sub>(<i>t</i>) is e...
<p>(A) Example traces of eLIF models implemented with Δ<sub><i>T</i></sub> = 15 mV (i) and 2 mV (ii)...
<p>(A) Average steady-state input resistance as a function of membrane voltage. Measures were taken ...
<p>(A) eLIF model <i>f-I</i> curve gain is reduced with more a negative V<sub><i>r</i></sub> value. ...
<p>(A) Steady-state membrane input resistance measures for different holding voltages under control ...
<p>(A) Plot of average stellate cell <i>f-I</i> curves using -5 ns (red), control (black) and 15 nS ...
This is an author-corrected version of the final published paper.Science increasingly involves compl...
<p>The optimization results for all cells are shown for three parameters: high voltage slope (<b>a<...
(A) Energy cost is plotted against reciprocal performance for the default model for parameter combin...
<p>(A) Average membrane voltage trajectories for initial spike approach in stellate cells under -5 n...
<p>(A): APs produced by two sets of parameters (shown in <a href="http://www.plosone.org/article/inf...
<p>(A)–(G) Comparison between the experimental observation (blue) and the model prediction (orange) ...
<p>Arrow direction shows model prediction for the change in intracellular concentrations and membran...
A. Frequency vs. Ibias curves for LIF (blue) and INaP (red) models. Observe the different scales for...
<p>Simulations of membrane potential (blue curves) and habituative transmitter (red curves) traces i...
<p>In <i>Step 1</i> (first row), the experimental spike train <i>S</i><sub>data</sub>(<i>t</i>) is e...
<p>(A) Example traces of eLIF models implemented with Δ<sub><i>T</i></sub> = 15 mV (i) and 2 mV (ii)...
<p>(A) Average steady-state input resistance as a function of membrane voltage. Measures were taken ...
<p>(A) eLIF model <i>f-I</i> curve gain is reduced with more a negative V<sub><i>r</i></sub> value. ...
<p>(A) Steady-state membrane input resistance measures for different holding voltages under control ...
<p>(A) Plot of average stellate cell <i>f-I</i> curves using -5 ns (red), control (black) and 15 nS ...
This is an author-corrected version of the final published paper.Science increasingly involves compl...
<p>The optimization results for all cells are shown for three parameters: high voltage slope (<b>a<...
(A) Energy cost is plotted against reciprocal performance for the default model for parameter combin...
<p>(A) Average membrane voltage trajectories for initial spike approach in stellate cells under -5 n...
<p>(A): APs produced by two sets of parameters (shown in <a href="http://www.plosone.org/article/inf...
<p>(A)–(G) Comparison between the experimental observation (blue) and the model prediction (orange) ...
<p>Arrow direction shows model prediction for the change in intracellular concentrations and membran...
A. Frequency vs. Ibias curves for LIF (blue) and INaP (red) models. Observe the different scales for...
<p>Simulations of membrane potential (blue curves) and habituative transmitter (red curves) traces i...
<p>In <i>Step 1</i> (first row), the experimental spike train <i>S</i><sub>data</sub>(<i>t</i>) is e...