<p>(A)–(G) Comparison between the experimental observation (blue) and the model prediction (orange) of the: (A) Mean voltage response to a hyperpolarizing current steps (30 and 60 pA). (B) Mean spike trajectory. (C)–(G) Firing responses to step current injections of 30, 100, 150, 200, and 350 pA, respectively. (H) I-f curve of the real (blue) and model (orange) cells. See also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002319#pbio.1002319.s005" target="_blank">S4</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002319#pbio.1002319.s006" target="_blank">S5</a> Figs.</p
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p><b>A.</b> Whole-cell voltage-clamp recording of membrane current of a mitral cell during perfusio...
Contemporary realistic mathematical models of single-cell cardiac electrical excitation are immense...
<p>(A) Tuft fluorescence signal during a train of four spikes evoked at 1 Hz in the real (light blue...
<p>(A) Membrane potential of the mitral cell model in response to a depolarizing current injection o...
<p>(A) Stochastic stimulation optimization sequence shows the difference between the experimental vo...
<p>(A) Top: raster plots showing a single unit response to ten repetitions of VNO stimulation by fem...
<p>Mitral cell: A. Visualization of a simulated <i>slice</i> network. We simulated ORN shock input t...
The number of mathematical models of cardiac cellular excitability is rapidly growing, and compact g...
<p>* = Significantly-different mean values via a Student's <i>t</i>-test, α ≤0.05. τ<sub>Inact</sub...
<p>(<b>A</b>) Third instar aCC motoneuron recording (i.) in presence of 0.2 mM Cd<sup>+2</sup> to bl...
<p><b>A.</b> Whole-cell current clamp recording of membrane potential change of a mitral cell during...
<p>The graphs show the membrane potential of the PG cell model in response to a depolarizing current...
<p><b>Comparison of experimental & simulated spike-type APs of two different shapes produced by syna...
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease m...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p><b>A.</b> Whole-cell voltage-clamp recording of membrane current of a mitral cell during perfusio...
Contemporary realistic mathematical models of single-cell cardiac electrical excitation are immense...
<p>(A) Tuft fluorescence signal during a train of four spikes evoked at 1 Hz in the real (light blue...
<p>(A) Membrane potential of the mitral cell model in response to a depolarizing current injection o...
<p>(A) Stochastic stimulation optimization sequence shows the difference between the experimental vo...
<p>(A) Top: raster plots showing a single unit response to ten repetitions of VNO stimulation by fem...
<p>Mitral cell: A. Visualization of a simulated <i>slice</i> network. We simulated ORN shock input t...
The number of mathematical models of cardiac cellular excitability is rapidly growing, and compact g...
<p>* = Significantly-different mean values via a Student's <i>t</i>-test, α ≤0.05. τ<sub>Inact</sub...
<p>(<b>A</b>) Third instar aCC motoneuron recording (i.) in presence of 0.2 mM Cd<sup>+2</sup> to bl...
<p><b>A.</b> Whole-cell current clamp recording of membrane potential change of a mitral cell during...
<p>The graphs show the membrane potential of the PG cell model in response to a depolarizing current...
<p><b>Comparison of experimental & simulated spike-type APs of two different shapes produced by syna...
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease m...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p><b>A.</b> Whole-cell voltage-clamp recording of membrane current of a mitral cell during perfusio...
Contemporary realistic mathematical models of single-cell cardiac electrical excitation are immense...