Cell membrane model validation.

<p>Arrow direction shows model prediction for the change in intracellular concentrations and membrane potential for a change in extracellular ion concentrations or inhibition of membrane transporter as indicated by the panel label. The color of the arrow indicates how the model compares with experimental data, summarised in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060323#pone-0060323-t004" target="_blank">Table 4</a>. Black arrows indicate where the model matches experimental data, white arrows indicate where there is no or inconsistent data, gray arrows indicate where no change was observed experimentally and striped arrows indicate where the model does not match experimental data. Data was considered inconsistent if different studies reported opposite changes in intracellular ion concentration or membrane potential in response to a change in extracellular ionic concentrations (for example the change in membrane potential following a decrease in ). In cases where one study reported no change in intracellular ion concentration or membrane potential and another found a change, it was assumed that the change was correct (for example the change in in response to an increase or a decrease in ). For example in panel A) corresponding to a decrease in (as indicated by the panel label), the experimental data comes from row 1 of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060323#pone-0060323-t004" target="_blank">Table? 4</a>. The model predicts that decreases and that and increase, consistent with experimental measurements and the arrows are shaded black. There is no consistent observed change in the transmembrane potential so the arrow remains white. No data is available for the change in in response to a decrease in so the arrow remains white. The model predicts a decrease in yet experimental measurements found an increase, hence the arrow is striped.