Modulation of stellate cell input-output responses with artificial changes in membrane conductance implemented using dynamic clamp.

<p>(A) Plot of average stellate cell <i>f-I</i> curves using -5 ns (red), control (black) and 15 nS (blue) levels of artificial conductance, as well as in the presence and absence membrane voltage fluctuations. (B) Plot of average gain measured using linear regression using -5 nS, control and 15 nS with (open symbols) and without (closed symbols) membrane voltage fluctuations. (C) Change in rheobase (i) and initial spike rate (ii) in stellate cell <i>f-I</i> curves resulting from the introduction of membrane voltage fluctuations with -5 nS, control and 15 nS levels of added conductance. (<i>D</i>) Plot of average stellate cell spike-probability curves under -5 ns (red), control (black) and 15 nS (blue) with and without membrane voltage fluctuations. (E) Change in rheobase (i) and sigmoid slope factor (ii) in stellate cell spike-probability curves under -5 nS, control and 15 nS resulting from the introduction of membrane voltage fluctuations.