Novel compounds that dose-dependently improve glucose tolerance in mice.

<p>The indicated doses of novel compounds (codes and chemical structures shown above the bar graphs) were orally administered to male C57BL/6J mice 45 min before a standard oral glucose tolerance test was started (3 g/kg). Effects on the total area under the glucose curve (AUC; <b>A</b>), and on the peak increment in blood glucose 30 min after glucose administration (<b>B</b>) are given as % of mean values of the corresponding vehicle group. Means±SEM; n = 6–16 each; *p<0.05; †p<0.01; ‡p<0.001 vs. vehicle (= 100%; open bars).