Effect of compound 21 administration on glucose intolerance in KK-Ay mice.

<p>Effect of administration of compound 21 (C21) on concentrations of blood glucose (<b>A</b>) and serum insulin (<b>B</b>) in oral glucose tolerance test (OGTT), and glucose concentration in insulin tolerance test (ITT) (<b>C</b>) in KK-Ay mice. Male KK-Ay mice were treated as described in ‘<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048387#s2" target="_blank">Methods</a>’. Some KK-Ay mice treated with C21 were concurrently administered GW9662, a PPARγ antagonist. OGTT and ITT were performed after 16 hours and 4 hours of fasting, respectively (n = 8–10 per group). Data are expressed as mean ± SEM. *<i>p</i><0.01 vs. control; †<i>p</i><0.01 C21 vs. C21+GW9662.