Acute and Chronic Effect of Glibenclamide on Glucose Tolerance and Blood Glucose Levels

<div><p>In each graph, asterisks indicate control group is significantly different (<i>p</i> < 0.05) from the test group at the specified time point.</p> <p>(A) GTTs on 6-wk-old WT mice (<i>n</i> = 10) fasted for 12 h and intraperitoneally injected with 1.5 g/kg glucose and glibenclamide simultaneously.</p> <p>(B) Blood glucose response of fed 6-wk-old mice (<i>n</i> = 10) to acute injection of glibenclamide.</p> <p>(C) Fed blood glucose from WT and Kir6.2 knockout (Kir6.2KO) mice implanted with placebo or glibenclamide pellets (0.0001 or 2.5 mg/pellet) over time.</p> <p>(D) Individual values of fed glucose (plus mean and SEM) from WT control and glibenclamide-pelleted mice, as well as Kir6.2-KO and SUR1-KO mice implanted with 2.5 mg pellets, at 1 and 42 d after implantation.</p> <p>Each group in (C) and (D) contained ten to 15 mice.</p>