Effects of DC260126 on glucose tolerance, insulin secretion and insulin sensitivity in <i>db/db</i> mice.

<p>(A, D) No significant change was observed on blood glucose levels during the OGTT between vehicle and DC260126 treated mice. After intragastric administration with 2 g glucose per kg body weight at 0 min, blood glucose concentrations at the indicated times in the graphs. The area under curve (AUC) was calculated in right. (B, E) Serum insulin levels after intragastric administration of 2 g glucose per kg body weight. Insulin secretion during phase 1 (0 – 20 min) and phase 2 (20 – 120 min) was calculated by AUC. (C, F) Blood glucose levels at the indicated time following intraperitoneal injection of 1 U insulin per kg body weight in mice. AUC was shown in right. * indicated significant differences v.s. the vehicle group (n = 8, * <i>p</i><0.05, *** <i>p</i><0.001).