Proteins in different environmental interaction classes and the corresponding enriched pathways after concurrent G and HT stimuli.

<p>The color bar shows the range of fold changes. Pathway analysis was done using <i>GeneMANIA</i> Cytoscape plugin[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134099#pone.0134099.ref042" target="_blank">42</a>]. Bar graphs were generated in <i>Graphpad Prism</i>. A) Non-specific environmental response (NER) proteins to individual and concurrent HT and G environmental stimuli. The theoretical expression patterns are shown in the top panel. The fold changes of 175 NER proteins are shown as a heatmap. B) The theoretical expression patterns for discordant environmental interaction are shown in the top panel. The fold changes of 41 proteins are shown as a heatmap. C) The theoretical expression patterns for suppression environmental interaction are shown in the top panel. The fold changes of the 58 proteins affected by suppression are shown as a heatmap. D) Bar graph shows the–log q-value of enrichments for the top 5 pathways for the non-specific environmental response proteins. E) Bar graph shows the–log q-value of enrichments for the top 5 pathways in the list of proteins affected by discordant environmental interaction. F) Bar graph shows the–log q-value of enrichments for the top 5 pathways in the list of proteins affected by suppression environmental interaction.