The Interactions of Proteins Representing the Gene Classifier

<div><p>Of the gene products most frequently present in the gene classifier, 33 proteins are present in the Ingenuity database. These are represented by colored symbols (green symbols indicate proteins that have higher induction after irradiation in NRs, and red symbols indicate proteins that have higher induction in ORs). The intensity of the colors indicates the difference between the groups in the magnitude of induction. The connecting proteins are represented by empty symbols. Only three of the colored proteins are not directly or indirectly linked through a connecting protein.</p> <p>Inset: The degree distribution of the proteins in the sub-network. For each protein we calculated the number of interactions in the total human interaction network (protein degree, <i>z</i>) and plotted it against the proportion of each protein degree, <i>P</i>(<i>z</i>). Vertical blue and black lines indicate the average protein degree, showing that the classifier proteins (blue) and the connecting proteins (black) represent two separate populations (<i>p</i> < 0.001, Wilcoxon test).</p>