Protein-protein interaction networks of the major DEGs.

(A) Volcano-plot figures of the DEGs in the comparison groups of T_1/CT (the left side), PPI networks of the major DEGs of T_1/CT comparison (the right side). (B) Volcano-plot figures of the DEGs in the comparison groups of T_48/T_1 (the left side), PPI networks of the major DEGs of T_48/T_1 comparison (the right side). On the left side of this Figure: plots indicated the expressed genes; the red color referred to up-regulated DEGs; the blue color represented down-regulated DEGs; the black plots indicated non-DEGs (absolute value of Log2FoldChange ≤ 1.0); X axes represented the values of Log2FoldChange; Y axes represented the values of |-Log10FDR|; the higher the value on the Y axes, the more credible the value of the DEG; and the gray dash lines indicated the filter lines for the major DEGs (P-value 10 FDR ≥ 10.0, absolute value of Log2FoldChange ≥ 3.0). On the right side of this figure: the nodes represented the genes/proteins, the edges represented the protein-interactions, the larger and brighter the node was, the more count-numbers of proteins that interact with this node, and the thicker and brighter the edge was, the higher the value of Edgebetweenness in this edge.