Distribution of interaction p-values across genes mapping to pathways with weak interaction signals.

<p>P-values of interaction on the gene-level are given on a minus log₁₀ scale (y-axis), i.e. higher bars represent smaller interaction p-values. (A) Genes of the mitochondrial dysfunction pathway interacting with PM10 and packyears exposure between surveys on FEV₁/FVC decline. (B) Genes of the methane metabolism pathway interacting with PM10 and packyears exposure between surveys on FEF_25–75 decline. (C) Genes of the apoptosis signaling pathway interacting with PM10 and packyears exposure between surveys on FEV₁ decline.