Manhattan plot of interaction p-values derived from the MESA genome-wide interaction analysis.

<p>Linear regression models, including main effects for SNP and asthma, and an interaction term for SNP × asthma, were used. Models were also adjusted for age, sex, and the first principal component. The red (upper) line represents the genome-wide significant p-value (0.05/721,893 = 6.93×10⁻⁸). The blue (lower) line represents the genome-wide suggestive p-value of 5×10⁻⁷.