Manhattan plot of genetic association.

<p>The strength of association for known (bottom) and unknown (top) metabolites is indicated as the negative logarithm of the p-value for the linear model (see Methods). Only metabolite-SNP associations with p-values below 10⁻⁶ are plotted (grey circles). Triangles represent metabolite-SNP associations with p-values below 10⁻⁴⁰. Horizontal lines indicate the threshold for genome-wide significance ( = 1.6×10⁻¹⁰ corresponding to α = 0.05 after Bonferroni correction); red vertical dashes indicate loci at which this threshold is attained.