Hepatic oxylipin profiles in WT and sEH-KO mice.

<p>(A), (B): Metabolic deficiency of sEH resulted in decreased DiHOME/EpOME- (A) as well as 14,15-DHET/14,15-EET-ratios (B). (C), (D): The hepatic levels of 5- through 19-HETE (C) as well as the hepatic 20-HETE levels (D) were not different in WT and sEH-KO mice. Results are given as mean ± SEM (n = 5–6 per group). Statistically significant differences were observed as indicated: * p<0.05, ** p<0.01 vs WT.