Variant distribution of the complete dataset.

<p>A) Heatmap of number of variants per tumour group. On the y-axis the different primary tumour site is depicted and on the x-axis all genes with mutational data are depicted. The relative number of mutations is defined as the number of mutations normalized per number of samples in the tumour group. B) co-occurrence of different variants in colorectal tumours. The size of the circle around a gene is indicative of the number of times a variant is identified in the gene. The lines represent co-occurrences between genes where the line thickness indicates the number of co-occurrences. The colour of the circles indicates the function of the gene: green–tumour suppressor genes and oncogenes, purple–receptor tyrosine kinases, pink–PI3K pathway, yellow–KRAS/BRAF pathway.