Cancer-type-specific mutational hotspots and mutational hotspots shared by several cancer types.

<p>A. shows the distribution of mutational hotspots for different cancer types within a given domain instance. B. shows mutational hotspot distribution patterns of different domain instances (encoded by different genes) that each correspond to the same protein domain type. Mutational hotspots are shown as balls and sticks, domain instances are shown as boxes. Mutational hotspots in different colors represent mutations in different cancer types.