Heatmap of Patients with a Variant in an Oncodomain Hotspot for the PKc domain.

<p>Visual representation and hierarchical clustering of oncodomain hotspots on genes that were significant in MutSigCV. For each gene in each cancer type, the number of patients in oncodomain hotspots is quantified and the cell is color-coded if the gene had any patients in oncodomain hotspots (blue), if it was significant in MutSigCV (green) or both (purple). Only the top ten genes based on the gene name’s co-occurrence with the “cancer” MeSH term are shown. Here, cancer types are grouped via hierarchical clustering to show similar mutational patterns. Enumerated in each cell are the proportion of patients with a somatic variant in an oncodomain hotspot (numerator) compared to the number of patients that had a somatic variant anywhere in the protein domain region (denominator).