Downstream target gene profiles clustering with tumor suppressor genes (TSGs) and oncogenes (OCGs).

<p>The heat map shows a two-color representation of the regulatory relationship between modulators (TSGs and OCGs) and downstream target genes. A red colored cell in the grid indicates that the row TSG or OCG is inferred to regulate the column target gene. A blue colored cell in the grid indicates that the row TSG or OCG has no influence on the column target gene. The modulators’ dendrogram represents a hierarchical clustering of TSGs and OCGs based on their target gene profiles. The modulators’ dendrogram is divided into two branches with six clusters marked with different colors. The most significant enriched functional annotations are marked along the right of each cluster. Take the first maroon cluster in the TSG branch as an example: the enriched genes are involved in DNA damage and repair. The TSG-specific target genes are marked in red and the OCG-specific target genes are marked with yellow in the top panel. In addition, the TSG-specific target genes are also represented in red and the OCG-specific target genes are represented as a whole with yellow in the right panel. The arrow from TSG-specific target genes represents their regulatory effects on the ErbB signaling pathway, and the arrow from OCG-specific target genes represents their anti-apoptosis effects as apoptosis negative regulators.