The distribution of somatic mutations in different breast cancer subtypes of the 313 breast cancer patients.

a. The graphical summary of somatic mutations of the 4 genes in molecular subtypes. All of the 190 tumor samples with 4 gene somatic mutations are grouped into 5 groups: luminal A (n = 46), luminal B (n = 81), basal-like (n = 29), HER2-enriched (n = 22) and unknown (n = 11). The stripe panel shows every specific case harboring the 4 gene mutation with different mutation types. One stripe indicates one patient. Green stripe indicates missense mutation; Blue stripe indicates frameshift mutation; Red stripe indicates nonsense mutation; Black stripe indicates split site mutation; Dark Gray stripe indicates silent mutation; Cyan stripe indicates inframe indel mutation; Yellow star indicates mutation recorded in COSMIC database. b. The somatic mutation frequency of AKT1, PTEN, PIK3CA and TP53 in different breast cancer subtypes. The frequency of somatic mutations for individual gene is shown in the bar chart in various groups according to molecular subtypes of breast cancer. These groups include All (N = 313), luminal A (N = 86), luminal B (N = 128), basal-like (N = 40), HER2-enriched (N = 37) and unknown (N = 22).