<i>Car3 -/-</i> does not affect high-fat diet-induced insulin-resistance.

<p>Fasting and fed blood glucose (A) and serum insulin (B) from wild type (WT) and <i>Car3 -/-</i> (KO) mice fed standard chow (n = 7–8) or high-fat diet (n = 8–9) for 10 weeks. (C) Oral glucose tolerance test (with area under the curve below) performed on standard chow (n = 7–8) and high-fat diet (n = 4–5) mice after 11 weeks on the respective diet regime.