Chemical structure of IMB5043 and its effect on cancer cell lines.

<p>(A) Chemical structure of IMB5043. (B) IC₅₀ of IMB5043 in various cancer cells. Cells were treated with different concentrations of IMB5043 for 24 h, and IC₅₀ is calculated. Data shown are means ± SD. (C). Effect of IMB5043 on the morphology of SMMC-7721 cells were observed by bright field microscopy (100×). (D). Effect of IMB5043 on the nucleus of SMMC-7721 cells were observed by fluorescent microscopy (200×). The nucleus was staining by Hoest33342. (E) Effect of IMB5043 on the nucleus of SMMC-7721 cells were observed by Electron Microscopy (6000×). SMMC-7721 cells were incubated with indicated concentration of IMB5043 for 24 h. The representative picture is shown.