Peculiarities of changes in endogenous intoxication indicators in the dynamics of the experimental periodontitis development

Olekshij P. V., Regeda M. S. Peculiarities of changes in endogenous intoxication indicators in the dynamics of the experimental periodontitis development. Journal of Education, Health and Sport. 2023;13(2):309-314. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.13.02.044 https://apcz.umk.pl/JEHS/article/view/43433 https://zenodo.org/record/7802637 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.02.2023. Revised: 10.02.2023. Accepted: .24.02.2023. UDC: 616.314.18-002.4-099]-092.4/.9 Peculiarities of changes in endogenous intoxication indicators in the dynamics of the experimental periodontitis development P. V. Olekshij, M. S. Regeda Danylo Halytsky Lviv National Medical University Lviv Medical Institute Abstract The aim of our work was to investigate the peculiarities of changes in endogenous intoxication rates: medium mass molecules (MMM) and erythrocyte intoxication index (EII) in the blood of guinea pigs in the experimental periodontitis formation. The results of biochemical studies showed that at all stages of the development of experimental periodontitis, there is a consistent increase in the degree of endogenous intoxication with their dominance on the 15 th day of the experiment relative to the control, namely, the content of medium-mass molecules (МMМ254, МMМ280) and the erythrocyte intoxication index (EII) increased in blood, respectively, by 24.8% (р≤0.05), 28.2% (р≤0.05) and 34.7% (р≤0.05) compared to the first group of animals, which indicates an increase in the processes and the important role of metabolites of endogenous intoxication and their participation in the mechanisms of formation of experimental periodontitis. Key words: periodontitis; stress; endogenous intoxication; medium mass molecules; erythrocyte intoxication index