The level of endogenic intoxication in the dynamics of development of experimental contact dermatitis and experimental pneumonia and their correction by thiotriazoline

Regeda-Furdychko M. M. The level of endogenic intoxication in the dynamics of development of experimental contact dermatitis and experimental pneumonia and their correction by thiotriazoline. Journal of Education, Health and Sport. 2019;9(11):287-292. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2019.09.11.026 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2019.09.11.026 http://dx.doi.org/10.5281/zenodo.3585786 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 06.11.2019. Revised: 14.11.2019. Accepted: 29.11.2019. UDK: 616.24-002-036.12-093 THE LEVEL OF ENDOGENIC INTOXICATION IN THE DYNAMICS OF DEVELOPMENT OF EXPERIMENTAL CONTACT DERMATITIS AND EXPERIMENTAL PNEUMONIA AND THEIR CORRECTION BY THIOTRIAZOLINE M. M. Regeda-Furdychko Lviv Medical Institute Abstract Тhe aim of our work was to find out the peculiarities of changes of endogenous intoxication indices in guinea pig blood during the formation of combined pathology - experimental contact dermatitis and experimental pneumonia and correction of their disorders with thiotriazoline. The paper found a gradual increase in the molecules of medium mass and erythrocyte index of intoxication in guinea pig serum with experimental contact dermatitis and experimental pneumonia with the highest degree of expression on the 18th day of the experiment, and this may be may indicate the development of endogenous intoxication of the animal body. At the same time, the use of the drug thiotriazoline caused the decrease of the studied indicators, which gives grounds to state its positive effect on certain markers of endogenous intoxication and the feasibility of further research. Key words: contact dermatitis; pneumonia; endogenous intoxication; thiotriazoline