The state of individual components of humoral immunity of guinea pig blood in the dynamics of the formation of experimental periodontitis and immobilization stress and correction of their disorders by thiocetam

Regeda M. S., Olekshij P. V. The state of individual components of humoral immunity of guinea pig blood in the dynamics of the formation of experimental periodontitis and immobilization stress and correction of their disorders by thiocetam. Journal of Education, Health and Sport. 2022;12(10): 208-213. eISSN 2391-8306. https://apcz.umk.pl/JEHS/article/view/40617 https://zenodo.org/record/7250188 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2022; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 03.10.2022. Revised: 12.10.2022. Accepted: 25.10.2022. UDC: 616.311.2-002+616.314.17-008.6):612.014.484:616.155.37]-092.9 The state of individual components of humoral immunity of guinea pig blood in the dynamics of the formation of experimental periodontitis and immobilization stress and correction of their disorders by thiocetam M. S. Regeda, P. V. Olekshij Danylo Halytsky Lviv National Medical University Lviv Medical Institute Abstract The research found a rapid increase in the level of immunoglobulin M, starting from the 3 rd day of the experiment in comparison with the control values, which clearly indicates its activation in particular, and stimulation of humoral immunity in general. In the later stages (on the 5 th and 15 th days) of the formation of experimental periodontitis (EP) and immobilization stress (IS), an increase of this indicator by 93.5% and 94.2% was found, respectively, against group I guinea pigs (p≤0, 05). Regarding the content of immunoglobulin G in the blood, the highest growth rates were recorded in the fourth group of guinea pigs with EP and IS (on the 15 th day), which indicates a direct dependence of the duration of damaging factors on the level of these indicators and the body's ability to the protective response. The results of the treatment showed the effect and the reduction of the activity of the studied classes of immunoglobulins. Thus, the use of thiocetam led to a significant decrease in the content of Ig M and G in the blood, respectively, by 33.8% (p1≤0.05) and 41.7% (p1≤0.05) in EP and IS compared with the group of animals were not exposed to this drug, which indicates the immunocorrective effect of this drug on the studied tests. Key words: periodontitis; stress; immunoglobulins M, G; thioceta