Role of immune and metabolic processes in pathogenesis of the development of chronic periodontitis and pneumonia and correction of their impairment with quercetin. Journal of Education

Chuhai O. O., Reheda M. S., Reheda S. M. Role of immune and metabolic processes in pathogenesis of the development of chronic periodontitis and pneumonia and correction of their impairment with quercetin. Journal of Education, Health and Sport. 2017;7(2):786-798. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2542121 http://ojs.ukw.edu.pl/index.php/johs/article/view/6493 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.02.2017. Revised 24.02.2017. Accepted: 27.02.2017. ROLE OF IMMUNE AND METABOLIC PROCESSES IN PATHOGENESIS OF THE DEVELOPMENT OF CHRONIC PERIODONTITIS AND PNEUMONIA AND CORRECTION OF THEIR IMPAIRMENT WITH QUERCETIN O. O. Chuhai, M. S. Reheda, S. M. Reheda Danylo Halytsky Lviv National Medical University Abstract Chronic periodontitis is one of the most common diseases in dental practice, which shows annual tendency to increase. Nowadays, mechanisms of the formation of this pathology have been substantially studied. However, chronic periodontitis often occurs in combination with a concomitant pathology, in particular, pneumonia. Mechanisms of their formation under conditions of combined pathology and the role of the immune system have not been studied completely, prompting topicality of this research. The results of investigation of the peculiarities of changes in phagocytic leukocyte activity, indices of immune status in the blood, prooxidant and oxidant systems in the periodontium and lungs of guinea pig males in early (6th and 10th days) and late (20th day) periods of chronic periodontitis and in combination with experimental pneumonia have been presented in the article. It has been shown that early and late periods of chronic periodontitis formation, as well as in combination with experimental pneumonia pathology were characterized by increased phagocytic leukocyte activity, which was manifested by an increase (p<0.05) in phagocytic index in the blood, phagocytic number, nitroblue tetrazolium test, especially in late period of the disease. It has been proven that impairment of the balance between cell-mediated (decrease in T-lymphocyte level) and humoral (increase in B-lymphocyte level and circulating immune complexes (CIC)) immunities plays a significant role in pathogenesis of chronic periodontitis. It has been established that a combined pathology in early period of formation was accompanied by a depressive dynamics of cell-mediated immunity with further reduction (p<0.05) of T-lymphocyte level in late period. However, elevation (p