Characteristics of cytokine status in the pathogenesis of experimental periodontitis and immobilization stress

Olekshij P. V. Characteristics of cytokine status in the pathogenesis of experimental periodontitis and immobilization stress. Journal of Education, Health and Sport. 2021;11(08):504-509. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.08.056 https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.08.056 https://zenodo.org/record/5579592 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2021. Revised: 16.08.2021. Accepted: 31.08.2021. UDC: 616.314.18-002.4-092:612.176:616.155.3-097.37]-092.9 Characteristics of cytokine status in the pathogenesis of experimental periodontitis and immobilization stress P. V. Olekshij Lviv Medical Institute Abstract The aim of our study is to elucidate changes in the content of pro-inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and anti-inflammatory cytokines interleukin-10 (IL-10) in the blood serum of guinea pigs in the dynamics of experimental periodontitis and immobilization stress. The dynamics of the combined pathology (experimental periodontitis and immobilization stress) is accompanied by a pronounced progression of the proinflammatory group of cytokines - TNF-α and IL-6 against the background of declining functional activity of IL-10 at all stages of their formation (3 rd , 5 th and 15 th days) with an advantage on the 15 th day of the experiment. The data obtained indicate an imbalance of pro- and anti-inflammatory cytokines and impaired cytokinogenesis, which is important for the pathogenesis in this combined pathology. Key words: periodontitis; stress; cytokines