Cartoon diagrams of RAD52, BRCA2, BRCA1 and PALB2 showing specific domains in each gene. The diagrams were adapted from [19, 61–64]. Co-occurring mutations from Table 1 are color coded. Highlighted mutations are those with a high probability of being driver or pathogenic.</p
A. VEST and CHASM p-values for co-occurring RAD52 mutations listed in Table 1. For easy identificati...
<p>A summary chart of all RAS/RAF mutations in each patient group displays genes across in rows and ...
Section A. Comparison with other methods for discovering single driver mutation. Section B. Paramete...
A. Percent co-occurring mutations between the four genes using data from Table 1. Total percentage (...
All co-occurring mutations reported on COSMIC regardless of their pathogenicity or driver status. (D...
A. Distribution by type of mutation. The COSMIC mutations were partitioned into non-coding (5’ UTR, ...
<p>Coding mutations in known cancer genes (A) and candidate genes (B) are indicated with different c...
In human cells homologous recombination (HR) is critical for repair of DNA double strand breaks (DSB...
Growth rates and levels of ProA* (A) and ProB (B) in strains carrying the promoter mutation M1 and o...
<p>Each row represents a mutated gene and each column represents an individual tumor. Shown in green...
<p>Blackened symbols represent cancer-affected relatives. An arrow indicates the proband. Dx: age at...
<p>A) The Venn diagram indicates the number of genes showing non-synonymous mutation in type 1 strai...
<p>(A) Mutations in the XPD/ERCC2 protein domains. The diagram shows the ERCC2 protein with the four...
<p>A) Plotted on the x-axis is the observed number of coding sequence (CDS) mutations in each of the...
A) Number of mutations (left panel) and number of clones (right panel) in tumor types and subtypes w...
A. VEST and CHASM p-values for co-occurring RAD52 mutations listed in Table 1. For easy identificati...
<p>A summary chart of all RAS/RAF mutations in each patient group displays genes across in rows and ...
Section A. Comparison with other methods for discovering single driver mutation. Section B. Paramete...
A. Percent co-occurring mutations between the four genes using data from Table 1. Total percentage (...
All co-occurring mutations reported on COSMIC regardless of their pathogenicity or driver status. (D...
A. Distribution by type of mutation. The COSMIC mutations were partitioned into non-coding (5’ UTR, ...
<p>Coding mutations in known cancer genes (A) and candidate genes (B) are indicated with different c...
In human cells homologous recombination (HR) is critical for repair of DNA double strand breaks (DSB...
Growth rates and levels of ProA* (A) and ProB (B) in strains carrying the promoter mutation M1 and o...
<p>Each row represents a mutated gene and each column represents an individual tumor. Shown in green...
<p>Blackened symbols represent cancer-affected relatives. An arrow indicates the proband. Dx: age at...
<p>A) The Venn diagram indicates the number of genes showing non-synonymous mutation in type 1 strai...
<p>(A) Mutations in the XPD/ERCC2 protein domains. The diagram shows the ERCC2 protein with the four...
<p>A) Plotted on the x-axis is the observed number of coding sequence (CDS) mutations in each of the...
A) Number of mutations (left panel) and number of clones (right panel) in tumor types and subtypes w...
A. VEST and CHASM p-values for co-occurring RAD52 mutations listed in Table 1. For easy identificati...
<p>A summary chart of all RAS/RAF mutations in each patient group displays genes across in rows and ...
Section A. Comparison with other methods for discovering single driver mutation. Section B. Paramete...