<p>Blackened symbols represent cancer-affected relatives. An arrow indicates the proband. Dx: age at diagnosis; WT: wild-type; WT: wild-type; *<i>TP53</i> (p.R337H) mutation carriers and negative for <i>BRCA1/2</i>; **<i>TP53</i> (p.R337H) and <i>BRCA1</i> negative and <i>BRCA2</i> mutation carrier; ***<i>TP53</i> (p.R337H) negative an <i>BRCA1/2</i> negative.</p
<p>Index patients are indicated with an arrow while individuals affected with breast cancer are indi...
<p>Genotype is provided for tested members as m/n for heterozygous carriers and n/n for homozygous w...
<p>The index individuals initially screened are indicated with arrows. All cancer patients marked in...
<p>This pedigree represents the family history of cancer in patient number 3. The proband, or origin...
<p>Patients with breast cancer are marked with black half circles. Other cancer types are marked wit...
<p>Index patient is denoted with an arrow. Individuals with cancer are represented with in dark circ...
<p>Individuals with cancer are represented with dark circles or with dark squares; the type of cance...
<p>The white arrow indicates the phenocopy 8-i; the black arrowhead indicates the family proband (i....
<p>The index individual #42 in this family has BRCA1 p.V802*. mutation. Individuals with ovarian, br...
<p>Below the individuals, genotypes are presented for either p.S1653KfsX2 (M1), p.L2784R (M2), p.Y29...
<p>Index patients are indicated with an arrow while individuals affected with breast cancer are indi...
Cartoon diagrams of RAD52, BRCA2, BRCA1 and PALB2 showing specific domains in each gene. The diagram...
<p>Males and females are represented by squares and circles, respectively. Arrows indicate individua...
<p>(A) Family pedigree of BRC945, carrier of c.1037_1041delAAGAA [STOP358]. (B) Family pedigree of B...
* age. Abbreviation: Pr, prostate cancer; Leu, leukemia; Br, breast cancer; Thr, thyroid cancer; CRC...
<p>Index patients are indicated with an arrow while individuals affected with breast cancer are indi...
<p>Genotype is provided for tested members as m/n for heterozygous carriers and n/n for homozygous w...
<p>The index individuals initially screened are indicated with arrows. All cancer patients marked in...
<p>This pedigree represents the family history of cancer in patient number 3. The proband, or origin...
<p>Patients with breast cancer are marked with black half circles. Other cancer types are marked wit...
<p>Index patient is denoted with an arrow. Individuals with cancer are represented with in dark circ...
<p>Individuals with cancer are represented with dark circles or with dark squares; the type of cance...
<p>The white arrow indicates the phenocopy 8-i; the black arrowhead indicates the family proband (i....
<p>The index individual #42 in this family has BRCA1 p.V802*. mutation. Individuals with ovarian, br...
<p>Below the individuals, genotypes are presented for either p.S1653KfsX2 (M1), p.L2784R (M2), p.Y29...
<p>Index patients are indicated with an arrow while individuals affected with breast cancer are indi...
Cartoon diagrams of RAD52, BRCA2, BRCA1 and PALB2 showing specific domains in each gene. The diagram...
<p>Males and females are represented by squares and circles, respectively. Arrows indicate individua...
<p>(A) Family pedigree of BRC945, carrier of c.1037_1041delAAGAA [STOP358]. (B) Family pedigree of B...
* age. Abbreviation: Pr, prostate cancer; Leu, leukemia; Br, breast cancer; Thr, thyroid cancer; CRC...
<p>Index patients are indicated with an arrow while individuals affected with breast cancer are indi...
<p>Genotype is provided for tested members as m/n for heterozygous carriers and n/n for homozygous w...
<p>The index individuals initially screened are indicated with arrows. All cancer patients marked in...