Pathogenicity and driver probability values using the OPEN Cravat tool.

A. VEST and CHASM p-values for co-occurring RAD52 mutations listed in Table 1. For easy identification each mutation is highlighted by a different color. Those with significant p-values are indicated with one star (either VEST or CHASM) or two stars (both). B. VEST and CHASM p-values for co-occurring BRCA2 mutations listed in Table 1. For easy identification each mutation is highlighted by a different color. Those with significant p-values are indicated with one star (either VEST or CHASM) or two stars (both). C. VEST and CHASM p-values for co-occurring BRCA1 mutations listed in Table 1. For easy identification each mutation is highlighted by a different color. Those with significant p-values are indicated with one star (either VEST or CHASM) or two stars (both). D. VEST and CHASM p-values for co-occurring PALB2 mutations listed in Table 1. For easy identification each mutation is highlighted by a different color. Those with significant p-values are indicated with one star (either VEST or CHASM) or two stars (both). E. Sample information for the identified mutations. F. Coordinates for lollipop figures in S1 Fig. (XLSX)