Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme - Fig 7

Growth rates and levels of ProA* (A) and ProB (B) in strains carrying the promoter mutation M1 and other mutations relative to those of the strain carrying just M1. Black, no other mutations in head region; blue, intergenic mutation M2; red, synonymous mutations in codon 2; white, synonymous mutation in codon 3; magenta, synonymous mutation in codon 4; cyan, synonymous mutations in codon 6; yellow, non-synonymous mutation M5. Data points representing strains with M1 and two additional mutations are shown with colored stripes corresponding to the colors used for individual mutations. Error bars represent 1 SD.