(A) Spot assays assessing growth of parental, Med14-AID, and Med16-AID strains on YPD plates containing DMSO or 500 μM 3-IAA at 30°C. (B) PCA plot of replicate nsRNA-seq experiments performed in WT and med16Δ cells and Med16-AID cells treated with DMSO or 3-IAA. (C) Scatterplot of log2(fold changes) for Med16-regulated genes in WT and med16Δ cells and Med16-AID cells treated with DMSO or 3-IAA with kernel density estimates. (D) Sequence logos of the de novo motifs discovered in the promoters (-400 to +100 bp relative to TSS) of genes in Med16R clusters. (E) Dot plot of KEGG pathways enriched in Med16-up and Med16-down genes. (TIF)</p
<p>A) Diagram of <i>PDR5</i> as in Fig. 3. B) RT-qPCR analysis of <i>PDR5</i> RNA from non-drug trea...
<p>(A) Venn diagrams representing genes affected, either up-regulated or down-regulated in microarra...
Supplemental Table Legends: Table S1. Antibody manufacturers and clones Table S2. Significant dif...
(A) Western blot showing the kinetics of Med16-AID depletion upon 3-IAA treatment of cells. (B) Spot...
(A) PCA plot of replicate nsRNA-seq experiments performed in Med15/16-AID and Med15-AID cells treate...
(A) Western blots showing the kinetics of Med16-AID depletion and stability of TBP-3xFLAG-MNase upon...
(A) PCA plot of replicate nsRNA-seq experiments performed in Mot1/Med16-AID cells treated with DMSO ...
(A) Western blots showing the kinetics of Med15-AID and Med16-AID depletion upon 3-IAA treatment of ...
(A) Western blots showing the kinetics of Mot1-AID and Med16-AID upon 3-IAA treatment of double-degr...
(A) Boxplots of replicate log2 upstream/TESR Med8, Med5, and no-tag ChIP-seq signal from the WT kin2...
Figure S1. Schematic of drug-inducible sgRNA expression lentiviral vectors. Figure S2. Nucleotide se...
Western blots on (A) engineered HCC1806 and SUM159 cells with 0.5 μg/ml Dox-induced overexpression o...
<p>(A) qRT-PCR analysis of IL-8 in 16HBE cells treated with control or PDCD4 siRNA and infected with...
<p>Plates of cells (in quadruplicate) were treated with 1 μM of either compound or DMSO (1 μM) for 2...
<p>(A) Dot plot representing differentially expressed genes in NTKO and TKO cells from the microarra...
<p>A) Diagram of <i>PDR5</i> as in Fig. 3. B) RT-qPCR analysis of <i>PDR5</i> RNA from non-drug trea...
<p>(A) Venn diagrams representing genes affected, either up-regulated or down-regulated in microarra...
Supplemental Table Legends: Table S1. Antibody manufacturers and clones Table S2. Significant dif...
(A) Western blot showing the kinetics of Med16-AID depletion upon 3-IAA treatment of cells. (B) Spot...
(A) PCA plot of replicate nsRNA-seq experiments performed in Med15/16-AID and Med15-AID cells treate...
(A) Western blots showing the kinetics of Med16-AID depletion and stability of TBP-3xFLAG-MNase upon...
(A) PCA plot of replicate nsRNA-seq experiments performed in Mot1/Med16-AID cells treated with DMSO ...
(A) Western blots showing the kinetics of Med15-AID and Med16-AID depletion upon 3-IAA treatment of ...
(A) Western blots showing the kinetics of Mot1-AID and Med16-AID upon 3-IAA treatment of double-degr...
(A) Boxplots of replicate log2 upstream/TESR Med8, Med5, and no-tag ChIP-seq signal from the WT kin2...
Figure S1. Schematic of drug-inducible sgRNA expression lentiviral vectors. Figure S2. Nucleotide se...
Western blots on (A) engineered HCC1806 and SUM159 cells with 0.5 μg/ml Dox-induced overexpression o...
<p>(A) qRT-PCR analysis of IL-8 in 16HBE cells treated with control or PDCD4 siRNA and infected with...
<p>Plates of cells (in quadruplicate) were treated with 1 μM of either compound or DMSO (1 μM) for 2...
<p>(A) Dot plot representing differentially expressed genes in NTKO and TKO cells from the microarra...
<p>A) Diagram of <i>PDR5</i> as in Fig. 3. B) RT-qPCR analysis of <i>PDR5</i> RNA from non-drug trea...
<p>(A) Venn diagrams representing genes affected, either up-regulated or down-regulated in microarra...
Supplemental Table Legends: Table S1. Antibody manufacturers and clones Table S2. Significant dif...