Longitudinal comparisons of P10 with P21 of pooled protein plasma concentrations of six putative biomarkers.

Pooled untreated and SMN-ASO treated groups at P10 were longitudinally compared with pooled P21-treated groups for each genotype. Diagrams show (A) COMP, (B) DPP4, (C) SPP1, (D) CLEC3B, (E) VTN and (F) AHSG (see also S10 Table). (Dunn tests, Holm-corrected for multiple comparisons). Only comparisons leading to a significant difference are shown (*P ≤0.05; **P ≤0.01, ***P ≤0.001).