Single group comparison for protein plasma concentrations of six putative biomarkers.

Multiple comparisons of untreated and ASO-treated SMA and HET groups with and without PLS3 overexpression at P10 and P21 showing (A) COMP, (B) DPP4, (C) SPP1, (D) CLEC3B, (E) VTN and (F) AHSG concentrations in comparison to WT and WT+ASO, respectively (see also Table 1). (Dunn tests, Holm-corrected for multiple comparisons). Only comparisons leading to a significant difference are shown (*P ≤0.05; **P ≤0.01, ***P ≤0.001).