Plasma protein levels at M0 according to disease progression profiles.

<p>The cytokine profiles at M0 are shown for each group of patients: 16 rapid progressors (<b>A</b>), 19 progressors (<b>B</b>), and 11 slow progressors (<b>C</b>). Color code and statistical analyses are as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046143#pone-0046143-g002" target="_blank">Figure 2</a> (corrected threshold, p<0.005). The dotted horizontal line corresponds to the value in healthy donors. (<b>D</b>) Comparison of protein concentrations between the 3 groups of patients (SP, P and RP). Four representative cytokines are shown. The cytokines increasing significantly over groups were IP-10 and IL-10 (Cuzick’s test, p<0.007). When comparing the groups two by two, out of 28 proteins tested, the levels were different only for IP-10 (M&W test,***: p<0.005).