Tumor associated macrophage (TAM) infiltration is modulated by MMP-2/-9.

Panels A-F are representative sections stained with F4/80 to identify TAM infiltration in the various tumor cell/host mouse genotype combinations. A. WT-T in WT mouse. B. WT-T in 2KO mouse. C. WT-T in DKO mouse. D. DKO-T in WT mouse. E. DKO-T in 2KO mouse. F. DKO-T in DKO mouse. Scale bar 100 μm. G. Macrophage infiltration at the periphery (0.5 mm into the tumor). H. Macrophage infiltration into the center of the tumor (1 mm in from the tumor boundary). N = 6–8 tumors per condition. Data are means ± SEM.