Anti-CD115 mAb treatment depletes TAMs and M2-type macrophages in PyMT mouse tumors.

<p>F4/80 (A, B) or CD163 (C, D) expression in mammary tumors sampled at week 14 from mice treated with either PBS (A, C) or mAb AFS98 (B, D). Staining with irrelevant isotype control is shown in E, F. Sections shown were obtained from one mouse representative of 3 analyzed per group. Blue: DNA; Red: F4/80⁺ (A, B) or CD163⁺ (C, D) macrophages. F4/80 (G) and CD163 (H) staining were quantified in the tumors from mice treated with either PBS, control rat IgG or mAb AFS98.