Additional file 5: of Conserved regulation of RNA processing in somatic cell reprogramming

Figure S2. Distribution of gene expression changes. (A) Absolute log2 fold changes in gene expression between all iPSC and all fibroblast samples, irrespective of the species and study, are depicted in a cumulative fraction plot. Only genes with exactly one ortholog in each of human, mouse and chimpanzee were considered. The data in red is from genes that are associated with GO term “RNA splicing” (GO:0008380), while the data in blue is from remaining genes. The statistic and P value of the Kolmogorov-Smirnov test calculated for the data sets is indicated. (B) As in (A), but log2 fold changes are depicted in density plots and statistics (Student’s t-test; t and corresponding P value) for the difference of the means are indicated. (C and D) as in (A and B), respectively, but data for genes associated (red) or not associated (blue) with GO term “RNA processing” (GO:0006396) is plotted. (E and F) as in (A and B), respectively, but data for genes associated (red) or not associated (blue) with GO term “gene expression” (GO:0010467) is plotted. (G and H) as in (A and B), respectively, but data for genes associated (red) or not associated (blue) with GO term “spliceosomal complex” (GO:0005681) is plotted. (I and J) as in (A and B), respectively, but data for genes associated (red) or not associated (blue) with GO term “ribosome” (GO:0005840) is plotted. (PDF 521 kb