Additional file 9: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

Publication date

May 2019

DOI

10.6084/m9.figshare.8186345.v1

Abstract

Figure S7. Death receptor was up-regulated by c-Met inhibitor, PF. Representative Western blot results of Bcl2, DR4 and DR5 were shown. Membranes were re-probed for ACTB expression to show that similar amounts of protein were loaded in each lane in LPS246 cells (a) and 11GS079 PDCs (b). (1) primary treatment, (2) secondary treatment. (PPTX 156 kb

Extracted data

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Additional file 9: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

Open link

Publication date

May 2019

DOI

10.6084/m9.figshare.8186345.v1

Abstract

Extracted data

Topics

c-MetBiomolecule

protein

ACTB

receptorProtein

Western blot

Meibao Feng (3760681)
Jieqiong Feng (3760678)
Wuzhen Chen (719608)
Wubin Wang (3760687)
Xuesong Wu (1614739)
Jing Zhang (23775)
Fangying Xu (3760684)
Maode Lai (15338)

December 2016

(A) Quantification of the fold change of luciferase promoter reporter assays of NF-κB in LCN2-knockd...

Additional file 1: of Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Marion Wobser (515061)
Alexandra Weber (3661234)
Amelie Glunz (6478181)
Saskia Tauch (6478184)
Kristina Seitz (6478187)
Tobias Butelmann (6478190)
Sonja Hesbacher (348437)
Matthias Goebeler (475952)
René Bartz (6478202)
Hella Kohlhof (480871)
David Schrama (273819)
Roland Houben (96277)

March 2019

Table S1. Doubling time in hours of the investigated cell lines and fibroblasts B. Table S2. Real ti...

Additional file 2: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 7: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S5. Cell death was induced by PF and/ or rhTRAIL treatment. Representative Western blots of c...

Additional file 4: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S2. Expression levels of death receptors and c-Met receptor expression in STS cell lines. TRA...

Additional file 11: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S9. c-Met and rhTRAIL receptor expression levels in DDLPS. PDCs. c-Met inhibitor PF upregulat...

Additional file 5: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S3. c-Met inhibitor, PF and TRAIL treatment induced apoptosis in DDLPS cell lines. Apoptosis ...

Additional file 8: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S6. Induced expression levels of DR5 mRNA in DDLPS cells by PF and/ or rhTRAIL treatment. DR5...

Additional file 6: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S4. Efficacy of tumor cell suppression through combined treatment with the c-Met inhibitor, P...

Additional file 10: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S8. Effect of apoptosis by combination treatment with PF and/ or rhTRAIL and combined with DR...

Additional file 1: Figure S1. of Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

Chi Park (3537692)
Sung Cho (1269609)
Jae Du Ha (3001734)
Heejung Jung (1712437)
Hyung Kim (2030002)
Chong Lee (3537686)
In-Young Jang (3537695)
Chong Chae (3537689)
Heung Lee (3537683)
Sang Choi (2682997)

January 2016

Inhibition Curve. The inhibition percentage was measured in c-Met enzyme assay. The detailed assay p...

Additional file 7: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Expression data for differentially expressed apoptosis related genes in SKBR3 and SKBR3-L cells. Exp...

Additional file 11: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibitio...

Additional file 1: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Additional file 9: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S8. Autophagy inhibitors counteract palbociclib-mediated antagonism on bortezomib-induced cel...

Additional file 9: Figure S6. of Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition

Meibao Feng (3760681)
Jieqiong Feng (3760678)
Wuzhen Chen (719608)
Wubin Wang (3760687)
Xuesong Wu (1614739)
Jing Zhang (23775)
Fangying Xu (3760684)
Maode Lai (15338)

December 2016

(A) Quantification of the fold change of luciferase promoter reporter assays of NF-κB in LCN2-knockd...

Additional file 1: of Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Marion Wobser (515061)
Alexandra Weber (3661234)
Amelie Glunz (6478181)
Saskia Tauch (6478184)
Kristina Seitz (6478187)
Tobias Butelmann (6478190)
Sonja Hesbacher (348437)
Matthias Goebeler (475952)
René Bartz (6478202)
Hella Kohlhof (480871)
David Schrama (273819)
Roland Houben (96277)

March 2019

Table S1. Doubling time in hours of the investigated cell lines and fibroblasts B. Table S2. Real ti...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 7: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S5. Cell death was induced by PF and/ or rhTRAIL treatment. Representative Western blots of c...

Additional file 4: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S2. Expression levels of death receptors and c-Met receptor expression in STS cell lines. TRA...

Additional file 11: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S9. c-Met and rhTRAIL receptor expression levels in DDLPS. PDCs. c-Met inhibitor PF upregulat...

Additional file 5: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S3. c-Met inhibitor, PF and TRAIL treatment induced apoptosis in DDLPS cell lines. Apoptosis ...

Additional file 8: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S6. Induced expression levels of DR5 mRNA in DDLPS cells by PF and/ or rhTRAIL treatment. DR5...

Additional file 6: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S4. Efficacy of tumor cell suppression through combined treatment with the c-Met inhibitor, P...

Additional file 10: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S8. Effect of apoptosis by combination treatment with PF and/ or rhTRAIL and combined with DR...

Additional file 1: Figure S1. of Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

Chi Park (3537692)
Sung Cho (1269609)
Jae Du Ha (3001734)
Heejung Jung (1712437)
Hyung Kim (2030002)
Chong Lee (3537686)
In-Young Jang (3537695)
Chong Chae (3537689)
Heung Lee (3537683)
Sang Choi (2682997)

January 2016

Inhibition Curve. The inhibition percentage was measured in c-Met enzyme assay. The detailed assay p...

Additional file 7: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Expression data for differentially expressed apoptosis related genes in SKBR3 and SKBR3-L cells. Exp...

Additional file 11: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibitio...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Additional file 9: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S8. Autophagy inhibitors counteract palbociclib-mediated antagonism on bortezomib-induced cel...

Additional file 9: Figure S6. of Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition

Meibao Feng (3760681)
Jieqiong Feng (3760678)
Wuzhen Chen (719608)
Wubin Wang (3760687)
Xuesong Wu (1614739)
Jing Zhang (23775)
Fangying Xu (3760684)
Maode Lai (15338)

December 2016

(A) Quantification of the fold change of luciferase promoter reporter assays of NF-κB in LCN2-knockd...

Additional file 1: of Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Marion Wobser (515061)
Alexandra Weber (3661234)
Amelie Glunz (6478181)
Saskia Tauch (6478184)
Kristina Seitz (6478187)
Tobias Butelmann (6478190)
Sonja Hesbacher (348437)
Matthias Goebeler (475952)
René Bartz (6478202)
Hella Kohlhof (480871)
David Schrama (273819)
Roland Houben (96277)

March 2019

Table S1. Doubling time in hours of the investigated cell lines and fibroblasts B. Table S2. Real ti...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 9: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Abstract

Extracted data

Additional file 9: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Abstract

Extracted data

Topics

Related items

Topics

Related items