Additional file 4: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

Publication date

May 2019

DOI

10.6084/m9.figshare.8186309.v1

Abstract

Figure S2. Expression levels of death receptors and c-Met receptor expression in STS cell lines. TRAIL receptors, decoy receptor 1 (DcR1), decoy receptor 2, (DcR2), DR4, DR5, and c-Met expression levels in MFHino (a) SW872 (b), and HT1080 (c) cells, as analyzed by flow cytometry (isotype: shaded gray histogram; each receptors: bold black open histogram). (PPTX 129 kb

Extracted data

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Data Protection

Additional file 4: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

Open link

Publication date

May 2019

DOI

10.6084/m9.figshare.8186309.v1

Abstract

Extracted data

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Expression data for differentially expressed apoptosis related genes in SKBR3 and SKBR3-L cells. Exp...

Additional file 2: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 2: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S2.The impact of TRAIL and TNF-alpha treatment in SKBR3-Par, -L and the impact of TRAIL in HC...

Additional file 11: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S9. c-Met and rhTRAIL receptor expression levels in DDLPS. PDCs. c-Met inhibitor PF upregulat...

Additional file 9: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S7. Death receptor was up-regulated by c-Met inhibitor, PF. Representative Western blot resul...

Additional file 5: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S3. c-Met inhibitor, PF and TRAIL treatment induced apoptosis in DDLPS cell lines. Apoptosis ...

Additional file 7: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S5. Cell death was induced by PF and/ or rhTRAIL treatment. Representative Western blots of c...

Additional file 8: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S6. Induced expression levels of DR5 mRNA in DDLPS cells by PF and/ or rhTRAIL treatment. DR5...

Additional file 6: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S4. Efficacy of tumor cell suppression through combined treatment with the c-Met inhibitor, P...

Additional file 10: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S8. Effect of apoptosis by combination treatment with PF and/ or rhTRAIL and combined with DR...

Additional file 1: of Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Marion Wobser (515061)
Alexandra Weber (3661234)
Amelie Glunz (6478181)
Saskia Tauch (6478184)
Kristina Seitz (6478187)
Tobias Butelmann (6478190)
Sonja Hesbacher (348437)
Matthias Goebeler (475952)
René Bartz (6478202)
Hella Kohlhof (480871)
David Schrama (273819)
Roland Houben (96277)

March 2019

Table S1. Doubling time in hours of the investigated cell lines and fibroblasts B. Table S2. Real ti...

Additional file 1: Figure S1. of Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

Chi Park (3537692)
Sung Cho (1269609)
Jae Du Ha (3001734)
Heejung Jung (1712437)
Hyung Kim (2030002)
Chong Lee (3537686)
In-Young Jang (3537695)
Chong Chae (3537689)
Heung Lee (3537683)
Sang Choi (2682997)

January 2016

Inhibition Curve. The inhibition percentage was measured in c-Met enzyme assay. The detailed assay p...

Additional file 1: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Additional file 3: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S3. TRAIL expression in SKBR3-Par and SKBR3-L cells. A) TRAIL 1 and TRAIL 2 receptor expressi...

Additional file 7: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Expression data for differentially expressed apoptosis related genes in SKBR3 and SKBR3-L cells. Exp...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 2: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S2.The impact of TRAIL and TNF-alpha treatment in SKBR3-Par, -L and the impact of TRAIL in HC...

Additional file 11: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S9. c-Met and rhTRAIL receptor expression levels in DDLPS. PDCs. c-Met inhibitor PF upregulat...

Additional file 9: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S7. Death receptor was up-regulated by c-Met inhibitor, PF. Representative Western blot resul...

Additional file 5: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S3. c-Met inhibitor, PF and TRAIL treatment induced apoptosis in DDLPS cell lines. Apoptosis ...

Additional file 7: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S5. Cell death was induced by PF and/ or rhTRAIL treatment. Representative Western blots of c...

Additional file 8: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S6. Induced expression levels of DR5 mRNA in DDLPS cells by PF and/ or rhTRAIL treatment. DR5...

Additional file 6: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S4. Efficacy of tumor cell suppression through combined treatment with the c-Met inhibitor, P...

Additional file 10: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Jo (5626103)
Young Lee (101856)
Hyunjoo Lee (496066)
Jae Park (3409286)
Hyojun Park (615533)
Yoon-La Choi (225920)
Doopyo Hong (6737960)
Sung Kim (59072)

May 2019

Figure S8. Effect of apoptosis by combination treatment with PF and/ or rhTRAIL and combined with DR...

Additional file 1: of Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Marion Wobser (515061)
Alexandra Weber (3661234)
Amelie Glunz (6478181)
Saskia Tauch (6478184)
Kristina Seitz (6478187)
Tobias Butelmann (6478190)
Sonja Hesbacher (348437)
Matthias Goebeler (475952)
René Bartz (6478202)
Hella Kohlhof (480871)
David Schrama (273819)
Roland Houben (96277)

March 2019

Table S1. Doubling time in hours of the investigated cell lines and fibroblasts B. Table S2. Real ti...

Additional file 1: Figure S1. of Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

Chi Park (3537692)
Sung Cho (1269609)
Jae Du Ha (3001734)
Heejung Jung (1712437)
Hyung Kim (2030002)
Chong Lee (3537686)
In-Young Jang (3537695)
Chong Chae (3537689)
Heung Lee (3537683)
Sang Choi (2682997)

January 2016

Inhibition Curve. The inhibition percentage was measured in c-Met enzyme assay. The detailed assay p...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Additional file 3: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S3. TRAIL expression in SKBR3-Par and SKBR3-L cells. A) TRAIL 1 and TRAIL 2 receptor expressi...

Additional file 7: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Expression data for differentially expressed apoptosis related genes in SKBR3 and SKBR3-L cells. Exp...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 2: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S2.The impact of TRAIL and TNF-alpha treatment in SKBR3-Par, -L and the impact of TRAIL in HC...

Additional file 4: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Abstract

Extracted data

Additional file 4: of Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Abstract

Extracted data

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