Effects of tryptophan on glucose tolerance in DIO mice.

<p>A-C. Body weights (A), basal blood glucose (B), and serum insulin (C) levels in the mice fed with standard diet (SD) and 60% high fat diet (HFD) for eighteen weeks. D, G. Blood glucose levels after oral glucose load (1.0 g/kg) with tryptophan (150mM, 0.5g/kg, Trp) or vehicle (Veh) in 18-week-old mice fed with standard diet (SD, D) or high fat diet (HFD, G). E, H. Area under the curve (AUC) of glucose levels in D and G. F, I, J-M. Serum insulin (F, I), plasma GIP (J), GLP-1(K), acylated ghrelin (L), and desacyl ghrelin (M) concentrations 15 minutes after glucose load in the mice fed with standard diet (SD) or high fat diet (HFD). n = 6–7 per group, **: p<0.01, *: p<0.05.