Regional plots of replicated DMRs.

<p>CpGs within DMRs are annotated between colored vertical lines. (A) <i>RUNX1</i>, overlapping (4 of 5 probes) DMRs detected in the uncorrected and corrected model are highlighted separately, (B) <i>NAV1</i>, DMR detected in the uncorrected model, (C) <i>HOXA5</i> and (D) <i>HOXA6</i>, for both genes, DMRs detected in the corrected model. X-axis represents the chromosomal position and Y-axis represents methylation index (Beta value). <b>Tracks:</b> <i>CpG</i>: localization of CpG sites (UCSC, HG19), <i>RefGen</i>: Reference gene, blocks represents exonic regions, arrow indicates direction of transcription (UCSC, HG19), <i>CpG island</i>: blocks represent the localization of CpG islands (> 300bp, GC content > 50%, ratio observed/expected CpG > 0,6). <i>K562 H3k27me3</i>: histone 3 lysine 27 3 methylation mark in K562 (chronic myelogenous leukemia human cell line, gain of the mark is associated with decreased activity of gene). <i>K562H3k27ac</i>: histone 3 lysine 27 acetylation mark in K562 (chronic myelogenous leukemia human cell line, an increased level of this mark is associated with increased gene activity, i.e., active enhancer mark).