Gene Maps of the CpG Islands for the <i>VHL</i> and <i>SFRP1</i> genes demonstrating the Positioning of Probes and the Levels of Hypermethylation.

<p>This demonstrates the first exons of either the <i>VHL</i> gene (A) or the <i>SFRP1</i> gene (B) with the predicted CpG island region (green box), the position and methylation levels of the HumanMethylation27 BeadChip array probes (red lines) and, for <i>VHL</i> only, the position of the HumanMethylation450 BeadChip array probes (Black, grey and red boxes). The graphs for the HumanMethylation27 BeadChip array probes split the samples into two groups; those with tumor-specific hypermethylation (by the criteria described within) and those without. The average -values for the tumors and associated normals were graphed for each group and the standard deviation used to produce error bars. The boxes representing the HumanMethylation450 BeadChip array probes were colored black if their annotation designated them within the CpG island and grey if their annotation designated them outside of the CpG island. The red box represents the single probe that was both hypermethylated and designated within the CpG island.