Differentially methylated probes (DMPs) identified in disease vs. control comparisons.

<p>(<b>a</b>) Barplots representing the numbers of differentially methylated probes (DMPs) identified in each disease group vs. controls (Benjamini-Hochberg-adjusted <i>p</i>-value ≤0.05). The number of DMPs indicated in PSP vs. Control comparison is the union set of DMPs identified in dataset #1 and dataset #2. Red bars: hypermethylated DMPs, green bars: hypomethylated DMPs. (<b>b</b>) Venn diagram representing the overlap between DMPs in FTD vs. controls and PSP vs. controls. Red numbers: hypermethylated DMPs; green: hypomethylated DMPs. (<b>c</b>) Barplots representing DMPs classified by probe type. CpG island probes are overrepresented in both FTD vs. controls and PSP vs. controls. (<b>d</b>) Chromosome enrichment analysis: DMPs are significantly enriched in chromosomes 19, 22, and 17, only in PSP vs. controls (y axis: −log10 (p-value), hypergeometric test). (<b>e</b>) Circos plot <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004211#pgen.1004211-Krzywinski1" target="_blank">[65]</a> of chromosomes 19, 22, and 17 showing regional enrichment of DMPs (PSP vs. Control comparison, BH adjusted p-value ≤0.05, absolute average beta difference (aβD)>0.1) in one region on chromosome 17. Each chromosome was divided into 20 regions, which contain the equal number of CpG probes. Regions were colored according to the DMP density. Blue: low DMP density, yellow: high density. Circles from inner to outer represent FTD, PSP vs. controls, respectively.