DNA methylation patterns in dura- and scalp-derived fibroblasts.

<p>(A) Histogram of difference in DNAm levels at CpGs/probes between scalp and dura derived fibroblasts (on the proportion methylation scale). (B) The first principal component (PC1) of the DNAm data plotted against fibroblast sampling location (scalp versus dura). (C) Example significant differentially methylated region (DMR) that overlaps the gene <i>RUNX3</i>, with DNAm levels on the y-axis and genomic coordinates on the x-axis. (D) Example significant DNAm block, with DNAm levels on the y-axis and genomic coordinates on the x-axis. Gene annotation panels in C and D are based on Ensembl annotation–dark blue represents exons and light blue represents introns.